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Two Harbors, MN

We welcome you to experience what it feels like to thrive on your healthcare journey and in the presence of the Mineral Kingdom.  With a full selection of pure, live-source, whole-food supplements and complex homeopathy as well as a full-service medical spa (including Massage, CranioSacral Therapy & Clay Therapies), we thrive providing effective, natural options and technical excellence supported by the intuitive arts. We respect your health care journey and will match your readiness.

Studies

We have found, so far, roughly 700 studies and growing on hydrogen that have inspired us to do what we do. We have not paid for a single one to be made. These are all studies that have been created from thrid party funding. And of 700 studies, we could never put all of them here on this page. Below are some studies and articles that we have thoroughly enjoyed and wanted to share with you. 

Keep in mind, it is extremely important for you to understand that while we absolutely believe that everyone should be drinking hydrogen enriched water, we in no way make curative claims to any specific disease or pathology.

The below studies are shared for educational purposes only. They are not shared to indicate any outcome for anyone with a similar or same disease or pathology. The studies shows potential or possible outcomes. There are no protocols, drugs, natural methods, or techniques that are 100% effective. Every individual is different and diseases are complex.

Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals

Ikuroh Ohsawa, Masahiro Ishikawa, Kumiko Takahashi, Megumi Watanabe, Kiyomi Kishimaki, Kumi Yamagata, Ken-ichiro Katsura, Yasuo Katayama, Sadamitsu Asoh & Shigeo Ohta

Acute oxidative stress induced by ischemia-reperfusion or inflammation causes serious damage to tissues, and persistent oxidative stress is accepted as on of the causes of many common diseases including cancer. We show here that hydrogen (H2) has potential as an antioxidant in preventive and therapeutic applications. We include acute oxidative stress in cultured cells by three independent methods. H2 selectively reduced the hydroxyl radical, the most cytotoxic of reactive oxygen species (ROS), and effectively protected cells; however, H2 did not react with other ROS, which possess physiological roles. We used an acute rat model in which oxidative stress damage was induced in the brain by focal ischemia and reperfusion. The inhalation of H2 gas markedly suppressed brain injury by buffering the effects of oxidative stress. Thus H2 can be used as an effective antioxidant therapy; owing to its ability to rapidly diffuse across membranes, it can reach and react with cytotoxic ROS and thus protect agains oxidative damage.

Hydrogen–water enhances 5-fluorouracil-induced inhibition of Colon Cancer

Runtwene et al. (2015), Hydrogen-water enhances 5-fluorouracil-induced inhibition of colon cancer. PeerJ 3:e859; dOI 10.7717/peerj.859. 2015 April 7

Joshua Runtuwene 1,2, Haruka Amitani1, Marie Amitani1, Akihiro ASakawa1, Kai-Chun Cheng1 and Akio Inui1

1 Department of Psychosomatic Internal Medicine, Kagoshima University Graduate School of Medical and Dental Sciences, Kagoshima, Japan 2 Faculty of Medicine, Sam Ratulangi University, Manado, Indonesia

Abstract

Oxidative stress is involved in cancer development. Hydrogen (H2) is a potent antioxidant and exhibits anti-inflammatory and potentially anticancer-like activities. This study aimed to investigate the role of H2 in combination with 5-fluorouracil (5-FU) in cancer treatment both in vitro and in vivo using the colon 26 cell line.

The survival rate was determined using the Kaplan-Meier survival test, and cell viability was assessed using cell viability imaging kit and the MTT assay, and activation of the cell apoptosis pathway (Phosphorylated adenosine monophosphate activated protein kinase (p-AMPK), Apoptosis-inducing factor (AIF) and Caspase 3) were characterized by western blots. Hydrogen water administration improved the survival of mice with colon 26-induced cancer. Furthermore, hydrogen water enhanced cell apoptosis in cancer cells, resulting in a marked increase in the expression of p-AMPK, with respect to cell survival rate and anticancer functions. Additionally, high-content hydrogen water exhibited stronger anti-oxidative and anticancer activity than did the natural hydrogen water. In conclusion, high-content hydrogen water can inhibit colon cancer, particularly in combination with 5-fluorouracil.

Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance

Kajiyama S, Hasegawa G, Asana M, Hosoda H, Fukui M, Nakamura N, Kitawaki J, Imai S, Nakano K, Ohta M, Adachi T, Obayashi H,
Yoshikawa T

Oxidative stress is recognized widely as being associated with various disorders including diabetes, hypertension, and atherosclerosis. It is well established that hydrogen has a reducing action. We therefore investigated the effects of hydrogen-rich water intake on lipid and glucose metabolism in patients with either type 2 diabetes mellitus (T2DM) or impaired glucose tolerance (IGT). We performed a randomized, double-blind, placebo-controlled, crossover study in 30 patients with T2DM controlled by diet and exercise therapy and 6 patients with IGT. The patients consumed either 900 mL/d of hydrogen-rich pure water or 900 mL of placebo pure water for 8 weeks, with a 12-week washout period. Several biomarkers of oxidative stress, insulin resistance, and glucose metabolism, assessed by an oral glucose tolerance test, were evaluated at baseline and at 8 weeks. Intake of hydrogen-rich water was associated with significant decreases in the levels of modified low-density lipoprotein (LDL) cholesterol (ie, modifications that increase the net negative charge of LDL), small dense LDL, and urinary 8-isoprostanes by 15.5% (P b .01), 5.7% (P b .05), and 6.6% (P b .05), respectively. Hydrogen-rich water intake was also associated with a trend of decreased serum concentrations of oxidized LDL and free fatty acids, and increased plasma levels of adiponectin and extracellular-superoxide dismutase. In 4 of 6 patients with IGT, intake of hydrogen-rich water normalized the oral glucose tolerance test. In conclusion, these results suggest that supplementation with hydrogen-rich water  may have a beneficial role in prevention of T2DM and insulin resistance. 

Selective stimulation of the growth of anaerobic microflora in the human intestinal tract by electrolyzed reducing water.

Department of Physiology of Microorganisms, Biology Faculty, Lomonosov Moscow State University, 119992 Moscow, Russia.

96-99% of the "friendly" or residential microflora of intestinal tract of humans consists of strict anaerobes and only 1-4% of aerobes. Many diseases of the intestine are due to a disturbance in the balance of the microorganisms inhabiting the gut. The treatment of such diseases involves the restoration of the quantity and/or balance of residential microflora in the intestinal tract. It is know that aerobes and anaerobes grow at different oxidation-reduction potentials (ORP). The former require positive E(h) values up to +400 mV. Anaerobes do not grow unless the E(h) value is negative between -300 and -400 mV. In this work, it is suggested that prerequisite for the recovery and maintenance of obligatory anaerobic microflora in the intestinal tract is a negative ORP value of the intestinal milieu. Electrolyzed reducing water with E(h) values between 0 and -300 mV produced in electrolysis devices possesses this property. Drinking such water favors the growth of residential microflora in the gut. A sufficient array of data confirms this idea. However, most researchers explain the mechanism of its action by an antioxidant properties destined to detox the oxidants in the gut and other host tissues. Evidence is presented in favor of the hypothesis that the primary target for electrolyzed reducing water is the residential microflora in the gut. 
PMID: 15617863 [PubMed - indexed for MEDLINE]

Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes

Kosuke Aoki1, Atsunori Nakao2*, Takako Adachi1, Yasushi Matsui1 and Shumpei Miyakawa1

Abstract

Background: Muscle contraction during short intervals of intense exercise causes oxidative stress, which can play a role in the development of overtraining symptoms, including increased fatigue, resulting in muscle micro-injury or inflammation. Recently it has been said that hydrogen can function as antioxidant, so we investigated the effect of hydrogen-rich water (HW) on oxidative stress and muscle fatigue in response to acute exercise. Methods: Ten male soccer players aged 20.9 +/- 1.3 years old were subjected to exercise tests and blood sampling. Each subject was examined twice in a crossover double-blind manner; they were given either HW or placebo water (PW) for one week intervals. Subjects were requested to use a cycle ergometer at 75% maximal oxygen uptake (VO2) for 30 minutes, followed by measurement of peak torque and muscle activity throughout 100 repetitions of maximal isokinetic knee extension. Oxidative stress markers and creatine kinase in the peripheral blood were sequentially measured.

Results: Although acute exercise resulted in an increase in blood lactate levels in the subjects given PW, oral intake of HW prevented an elevation of blood lactate during heavy exercise. Peake torque of PW significantly decreased during maximal isokinetic knee extension, suggesting muscle fatigue, but peak torque of HW didn't decrease at early phase. There was no significant change in blood oxidative injury markers (d-ROMs and BAP) or creatine kinease after exercise. 

Conclusion: Adequate hydration with hydrogen-rich water pre-exercise reduced blood lactate levels and improved exercise-induced decline of muscle function. Although further studies to elucidate the exact mechanisms and the benefits are needed to be confirmed in larger series of studies, these preliminary results may suggest that HW may be suitable hydration for athletes. 

Effectiveness of Hydrogen Rich Water on Antioxidant Status of Subjects with Potential Metabolic Syndrome

Atsunori Nakao1, *, Yoshiya Toyoda1, Prachi Sharma1, Malkanthi Evans2 and Najla Guthrie2
1 Heart, Lung and Esophageal Surgery Institute, Department of Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA, 12513, USA, 2 KGK Synergized, Inc., London, ON, Canada, N6A 5R8
Published online 24 February, 2010

Summary:

Metabolic syndrome is characterized by cardio metabolic risk factors that include obesity, insulin resistance, hypertension and dyslipidemia. Oxidative stress is known to play a major role in the pathogenesis of metabolic syndrome. The objective of this study was to examine the effectiveness of hydrogen rich water (1.5-2 L/day) in an open label, 8-week study on 20 subjects with potential metabolic syndrome. Hydrogen rich water was produced, by placing a metallic magnesium stick into drinking water (hydrogen concentration; 0.55-0.65 mM), by the following chemical reaction; Mg + 2H20 to Mg (OH)2 + H2. The consumption of hydrogen rich water for 8 weeks resulted in a 39% increase (p<0.05) data-preserve-html-node="true" in antioxidant enzyme superoxide dismutase (SOD) and a 43% decrease (p<0.05) data-preserve-html-node="true" in thiobarbituric acid reactive substances (TBARS) in urine. Further, subjects demonstrated an 8% increase in high density lipoprotein (HDL)-cholesterol and a 13% decrease in total cholesterol/HDL-cholesterol from baseline to week 4. There was no change in fasting glucose levels during the 8 week study.

In conclusion, drinking hydrogen rich water represents a potentially novel therapeutic and preventive strategy for metabolic syndrome. 

Additional Studies

Disclaimer: There are hundreds of studies showing molecular hydrogen to have therapeutic benefits. Please visit www.synergyscience.com/studies to read additional clinical studies which are continually being added. The studies referred to here and on the adjoining pages are shared for educational purposes only. They are not shared to indicate any expected outcome for anyone with a similar or same disease or pathology. The results achieved in the studies should not be taken as an indicator of results you will experience. The study shows potential outcomes. There are no protocols, drugs, natural methods, or techniques that are 100% effective. Every individual is different and diseases are complex. 

The information on this page was provided by Paul A. Barattier, C.Ped., ©2013 Synergy Science, Inc. All Rights Reserved.